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Izquierdo

"Bases bioquímicas da persistência da memória"

Jorge H. Medina,Martin Cammarota & I Izquierdo. 


Some consolidated memories persist for just two or three days, whereas others may persist for many weeks or for a lifetime.  We have recently studied in some detail the mechanisms underlying long-term persistence. They involve several rounds of protein synthesis in the hippocampus several hours after consolidation is completed.  The first major protein synthesis is at 12 h from the original learning and includes the expression of bdnf.  this substance presumaly promotes synaptic growth through a mechanism involving erk 1/2 and promotes memory persistence lasting at least several weeks.  The bdnf production is triggered by dopaminergic fibers acting on d1 receptors in the hippocampus and coming from the ventral tegmental area (VTA).  The VTA cells are activated by nmda receptors.  other processes, one of them mediated by hippocampal c-fos and other factors, promote persistence by actions initiated at 18 or 24 h after training.

Palavras chaves:  Memory persistence -  hippocampal BDNF  -  VTA dopamine



 
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