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Bonnie Bassler
Dr. Bassler, a member of the National Academy of Sciences, is a Howard Hughes Medical Investigator and Professor of Molecular Biology at Princeton University.  She received a B.S. in Biochemistry from the University of California at Davis, and a Ph.D. in Biochemistry from the Johns Hopkins University.  She performed postdoctoral work in Genetics at the Agouron Institute, and she joined the Princeton faculty in 1994.  The research in her laboratory focuses on the molecular mechanisms that bacteria use for intercellular communication.  This process is called quorum sensing.  Dr. Bassler is the Director of Graduate Studies in the Molecular Biology Department, and she teaches both undergraduate and graduate courses.  Dr. Bassler was awarded a MacArthur Foundation Fellowship in 2002. 

She was elected to the American Academy of Microbiology in 2002 and made a fellow of American Association for the Advancement of Science in 2004.  She was given the 2003 Theobald Smith Society Waksman Award and she is the 2006 recipient of the American Society for Microbiology’s Eli Lilly Investigator Award.  

Bassler is an editor for Molecular Microbiology and Annual Reviews of Genetics, and she is an associate editor for the Journal of Bacteriology.  Among other things, she serves on grant, fellowship, and award review panels for the National Science Foundation, American Society for Microbiology, American Academy of Microbiology, Keck Foundation, and the Burroughs Wellcome Trust.  


Camilli, A. and B.L. Bassler. 2006. Bacterial small-molecule signaling pathways. Science 311:1113-1116.

Xavier, K.B. and B.L. Bassler. 2005. Interference with AI-2-mediated bacterial cell-cell communication. Nature 437:750-753

Neiditch, M.B., M.J. Federle, S.T. Miller, B.L. Bassler and F.M. Hughson. 2005. Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol. Cell 18:507-518.

Chen, X., S. Schauder, N. Potier, A. Van Dorsselaer, I. Pelczer, B.L. Bassler and F.M. Hughson. 2005. Structural identification of a bacterial quorum-sensing signal containing boron. Lets. Nature 415:545-549.

Semmelhack, M.F., S.R. Campagna, M.J. Federle and B.L. Bassler. 2005. An expeditious synthesis of DPD and boron binding studies. Organic Letters 7:569-572.

Ulrich,D.L., D. Kojetin, B.L. Bassler, J. Cavanagh and J. P. Loria. 2005. Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing. J. Mol. Biol. 347:297-307.

Xavier, K.B. and B.L. Bassler. 2005. Regulation of uptake and processing of the quorum sensing autoinducer AI-2 in Escherichia coli. J. Bacteriol. 187:238-248.

Semmelhack, M.F., S.R. Campagna, C. Hwa, M.J. Federle and B.L. Bassler. 2004. Boron binding with the quorum sensing signal AI-2 and analogs. Org. Lett.6:2635-2637.

Miller, S.T., K.B. Xavier, S.R. Campagna, M.E. Taga, M.F. Semmelhack, B.L. Bassler and F.M. Hughson. 2004. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum sensing signal AI-2. Mol. Cell 15:677-687.

Henke, J.M. and B.L. Bassler. 2004. Three parallel quorum sensing systems regulate gene expression in Vibrio harveyi. J. Bacteriol. 186:6902-6914

Lenz, D.H., K.C. Mok, B.N. Lilley, R. Kulkarni, N.S. Wingreen and B.L. Bassler. 2004. The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118:69-82.

Hammer, B.L. and Bassler, B.L. 2003. Quorum sensing controls biofilm formation in Vibrio cholerae. Mol. Microbiol. 50:101-114.
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