About the Conference
Scientific Program
Congress Information
Young Scientist Forum
About Salvador, Bahia
Mailing List
Technical Exhibits
Travel & Accommodations
Visa Information

Christine Clayton
Unconventional control of gene expression: mRNA degradation in trypanosomes

Christine Clayton, Angela Schwede, Chi-Ho Li, Mhairi Stewart, Praveen Delhi, Stuart Archer, Claudia Hartmann

Zentrum Für Molekulare Biologie Heidelberg, Germany

The Kinetoplastid parasites Trypansoma and Leishmania infect many millions of people and their domestic animals, causing significant mortality, morbidity and economic damage. They are transmitted from one mammal to the next by arthropod vectors. Adaptation to, and multiplication in, the two different hosts requires control of gene expression. Genes are arranged in polycistronic trasncription units and the precursors are cut into single-open-reading-frame units by trans splicing and polyadenylation. The efficiency of processing and the rate of degradation determine the mRNA level, and there is further control of translation. Most trypanosome mRNAs follow a degradation pathway in which the first event is  shortening of the 3' poly(A) tail by a complex containing the CAF1 protein. Very unstable mRNAs, in contrast, are directly attacked from the 5'-end. We are now trying to find out how different mRNAs are either directed towards the rapid degradation pathway, or protected from degradation.
Research institute: ZMBH
Keywords: Trypanosoma RNA degradation
© 2020 IUBMB2007