XXXV Reunião Anual da SBBqResumoID:9487



Microstructured Systems Obtained From Procetyl® AWS. Rheological study and Characterization through Peudoternary Phase Diagram


Sotiro, K. R.; Oliveira, A.G.2; Scarpa, M. V. 2



1 Programa de Pós-graduação em Ciências Farmacêuticas 2Departamento de Fármacos e Medicamentos –UNESP- São Paulo


Objective:  Microstructured system containig ProcetylâAWS as surfactnte, butyl adipate as oil phase and water was obtained with reduced amounts of surfactant and oil. The rheological study is widely used to understanding the physical stability and administration of these systens. The determination of the apparent viscosity and the rheologic behavior of semisolid products assumes each time more importance, therefore, it allows to understand better the characteristic of the vehicle and quality control of raw materials and pharmaceutical dosage forms. From these studies we can verify the effect of the consistency of the product in the drug release and cutaneous penetration2.  Methodology:  Procetyl AWS and butyl adipate were mixed, and after, purified water was added in order ternary phase diagram. In the phase diagram, the points of interest were selected, obtain the rheologic behavior was determined using rheometer CSL Carri-med model.  The process parameters were:  measure of draining, flow; temperature 25 ºC and the 37 °C cone plate; gap:  200; cone diameter: 2 cm; shear stress:  the 0-300 cm-1; shear stress in the return:  of 300-0 cm-1.  Results:  The phase diagram shows that the diagram, systems were obtained with minimum amount of procetyl (50%) and 5% of oil, rheograms presented non-Newtonian behavior with draining pseudoplastic and thixotropy.  The thixotropic behavior of the samples was confirmed through not overlapping of the curves ascending and descending2.  Conclusions:  The attainment of formulations with thixotropy characteristic is sufficiently interesting, therefore they deformed themselves during the application, become more fluid, facilitating the application and return to the initial viscosity after the use. This phenomena prevents that the product drains in the face.  Moreover, the thixotropic caracteristic can proves the increase of "shelf-life", since in the time remains constant viscosity2.

Financial support: FAPESP, CNPq and CAPES