Curcumin, a natural product isolated from rhizomes of Curcuma longa has been entered into phase I of clinical trials for chemoprevention by the National Cancer Institute. Other biological activities have been reported such as antioxidant, antimicrobial, anti-inflammatory and antiangiogenic. The diferuloylmethane structure of curcumin confers its hydrophobic propriety. However, its poor bioavailability and its fast metabolization once inside the cell, justifies the development of a controlled drug delivery system. Here in we analyze the delivery of curcumin from xanthan:galactomannan (X-G) hydrogel, as well as physical-chemical modification of hydrogel induced by curcumin. The X-G hydrogel was prepared by mixing the viscous solutions 1:1 (v/v) previously heated at 80 ^oC with or without curcumin. The dynamic rheological studies were performed to analyze the gelation behavior and the frequency dependence of the storage (G') and viscous (G'') moduli. All samples showed a gel-like response with G' significantly larger than G'', with both moduli being independent over the frequency studied (0.01–10 Hz). We also used the loss tangent (tan d = G"/G') in order to compare the gel strength of the samples. The tan d of the X-G hydrogel was higher for the X-G-curcumin system, suggesting a modification on the network when curcumin is present. The release of curcumin into solution was determined by fluorescence spectrophotometry. The systems X-G and X-G- curcumin were weighted, loaded into glass flasks covered with a PLLA film and incubated in 1.5 ml of 50 mM PBS (pH 7.2) at 37 ^oC  for 35 days. Aliquots of 0.5 mL were colleted weekly. During the first week of incubation, the curcumin release rate from the X-G curcumin hydrogel was 57.30 ng/ml/day and from curcumin-blended PLLA was 53.75 ng/ml/day. However, after 35 days the curcumin release rate from curcumin-blended PLLA and X-G curcumin hydrogel decreased to 10.60 ng/ml/day and 47.10 ng/ml/day, respectively. These results show that hydrogel prolonged the release of curcumin, suggesting that the X-G curcumin hydrogel may be useful as a controlled delivery system.