Extensive cutaneous injuries require clinical evaluation and treatment in order to provide wound healing to restore normal function. Among new and low cost alternatives, lectins have established conditions to improve wound healing. The aim of this work was to evaluate the effect of a topical treatment using Parkia pendula seed lectin (PpeL). Surgical round wounds (0.8 cm²) were produced aseptically in the dorsal region of albino Swiss mice (female, 8 weeks-old, 30.0 g, n=30/group). Each wound was evaluated and treated using daily doses, as follows: 150 mM NaCl (C Group) and 10 µg PpeL (T Group). The area measurement, presence of edema, granulation tissue and repithelization were analised. Samples were collected using sterile swabs at 2^nd, 7^th and 12^th days after surgery for bacteria isolation. Edema was observed until the 6^th and 7^th day for the T Group and C Group, respectively. At 8^th day, the granulation tissue was observed in all the Groups (66.7% Treated and 100% Controls). In the 11^th day, all T wounds were completely closed and repithelized, while only 60% of C lesions showed repithelization at this time. The microbiological analysis revealed the presence of Staphylococcus sp. in all wounds. The T Group showed a smaller frequency of contaminated wounds (52.3%, 36% e 17% at 2^nd, 7^th and 12^th days, respectively) when compared to the Control Group (83%, 70% and 45%, at 2^nd, 7^th and 12^th days, respectively). These results suggest a potential use of PpeL to improve cutaneous wound healing.