Epidemiological and experimental data suggest that iron excess may contribute to the development of cardiovascular diseases (CVD). As increased LDL-cholesterol, decreased HDL-cholesterol and increased oxidative stress have been implicated as risk factors for atherosclerosis, the present study was designed to determine whether iron excess and fibrate treatments alters serum lipids and oxidative stress in hypercholesterolemic hamsters. Male Syrian Hamsters were divided into four groups: Hypercholesterolemic group (H) was fed a 0,5% cholesterol diet; the HI group was fed the 0,5% cholesterol diet diet and given iron dextran injections, the HFi group was fed the 0,5% cholesterol and  0,5% of fibrate in the diet, the group HIFi received 0,5% cholesterol, fibrate and iron dextran. The hamsters were fed the diets for 8 wk, iron dextran injections were given during the wk 6th at doses of 10mg/d for five days and fibrate were given on wk 7th and 8th. Data were tested by two-way ANOVA. When interactions were significant, Tukey test was done to determine the specific differences between means. A difference of P<0.05 was considered significant. Iron dextran treatments increased serum iron in groups HI and HIFi. Excess iron increased plasma total cholesterol in hamsters (321,55 ± 94,24, 232,96 ± 34,66, 213,87 ± 32,67  and 192,74 ± 24,44  for HI, HIFi, HFi and H,  respectively). Plasma total cholesterol did not differ between groups H, HFI and HIFi. Excess iron also increased HDL and LDL-cholesterol fractions. Iron altered plasma levels of sulphydryl and paraoxonase. We could conclude that iron increased serum cholesterol and the hypercholesterolemic effect of the iron is reverted by fibrate.