A great portion of the population of the world is suffering from gastric lesions and the pathogenesis of this disease is well accepted but the exact mechanism involved in gastric lessions is still not clear. Recent reports demonstrated that ebselen (2 phenyl-1,2 benzisoselenazol-3(2II)-one) has antioxidant property and protect against gastric lesions induced by ethanol. We suggest that the diphenyl diselenide could have similar properties because both compounds have similar chemical and biochemical characteristics. The aim of this study was to examine whether diphenyl diselenide could protect the male rats stomachs against gastric lesions induced by ethanol. Gastric lesions and erosions were induced by ethanol according to the method of Robert et al. (1979). ROS prodution was determined spectrofluorometrically according Lebel et al. (1992) using the fluorescent dye 2’, 7’ dichlorodihydrofluorescein diacetate (DCFA). Diphenyl diselenide (10, 5, 1, 0.1 mg/kg) caused a significant protection and reversion against ethanol-induced gastric lesions and erosions when compared to the control group (p<0.05). Cimetidine (100 and 50mg/kg) was used as a positive control, because it has a gastroprotective effect being an anti-histaminic compound. DCFA oxidation experiments showed no differences in all treated groups in relation to the control group (p>0.05). Diphenyl diselenide protective mechanisms against lesion gastric are not related to lipid peroxidation. These results suggest that the diphenyl diselenide compound has a protective effect against ethanol-induced gastric lessions in rats. Further studies are necessary to clarify the mechanisms involved in diphenyl diselenide protective action.