The Pterodon sp. have been used to treat inflammations, throat pains and arthritis, among others. However few are the works that study the pharmacological potential of this plant and its toxic effects. We had previously demonstrated the anti-arthritic (Sabino et al., 1999), anti-inflammatory (Silva et al., 2000) and antinociceptive activity (Coelho et al., 2005) of Pterodon pubescens extracts. The aim of this study was to evaluate the antinociceptive and anti-inflammatory properties of Pterodon polygalaeflorus seeds (RB 350278, Jardim Botânico, RJ) on the writhing test and air pouch model. The extracts (EPpg, DEPpg and HEPpg) were obtained by maceration on ethanol, dichloromethane and hexane for 15 days, respectively and further evaporation under vacuum. All experiment were developed on SW male mice (n = 6/group), weighing 25-30 g. The EEPpg was tested in different doses in the air pouch model. On the first and third day, 5ml and 3ml of sterile air was inflated in the dorsal skin. On day six, group of animals received different doses of EEPpg, AAS (100 mg/kg) or the vehicle (ethanol 15% with 1.25% Tween-20) i.p. and after 1h was administrated carrageenan 1% into the air pouch. After 4 hour, the exsudate was harvested with NaCl 0.9% (1mL) containing EDTA 2mM.  The number of total cells was counted in a Neubauwer chamber. AAS inhibited 49% of cell migration, while EEPpg at 0.001 mg and 1 mg//kg exhibited 52.7% and 57% inhibition of cell migration (p<0.05), respectively. The abdominal constrictions were induced by i.p. injection of 0.6% acetic acid (10 ml/kg), one hour after treatment with extracts or controls. The number of writhes was noted for 10 min beginning 5 min after acetic acid injection. The antinociceptive activity was estimated as the reduction of the number of writhes in relation to the control group (vehicle). The AAS control group (100 mg/kg) induced 50% inhibition of the constrictions in relation to the control group (45.6±5.0). The number of writhes and the percentage of inhibition observed by oral treatment with the extracts was: EEPpg 0.1 mg/kg: 28.4±5.2 (36%) and 1 mg/kg: 24±5 (45.9%); DEPpg 0.1 mg/kg: 22.4±8 (37%) and 1 mg/kg: 21.4±5 (40%); HEPpg 0.01 mg/kg: 25±3.4 (45%), 0.05 mg/kg: 41.8±7.7 (8.3%), 0.1 mg/kg: 31±2.6 (32%), 0.5 mg/kg: 0±0 (100%) and 1 mg/kg: 0±0 (100%). We observe a significant antinociceptive activity in almost all doses testes (Tukey's test) with these extracts (P<0.05).  Supported by: UERJ, FAPERJ and CNPq.