Arg82p is a dual-specificity IP3-IP4 kinase and a pleiotropic regulator of an arginine-responsive ArgR-Mcm1 complex. It was demonstrated that an arg82D mutant presents defects in responses to nutrients, sporulation, mating and stress. In this context, we analyzed the cellular growth on different carbon sources of yeast presenting mutations in genes that encodes for proteins involved in the inositol phosphate metabolism. Our previous results demonstrated that arg82D does not grow on media containing ethanol, glycerol and galactose as sole carbon sources and does not present a second phase of growth as we can observe in a classical growth kinetic of the yeast Saccharomyces cerevisiae. Other studies have demonstrated that the mutant arg82D shows a high level of IP3 (Saiard, A. et al. 2000, FEBS Letters 468, 28-32). To investigate the relationship between IP3 levels into the cell and the severe phenotypes of the mutant arg82D, we decided to construct a double-mutant arg82D/plc1D and analyze the different phenotypes of this mutant. The double mutant presented the same phenotypes of the arg82D leading us to conclude that there is not a link between the level of IP3 and the growth deficient on different carbon sources. Recently our lab acquired the EUROSCARF collection of yeast mutant strains, so we decided to check if the arg82D from this collection would present the same response of the mutant we have been working. Intriguingly, the results were different, since the EUROSCARF mutant arg82D presented normal growth on different carbon sources. The mutations were verified in both strains by PCR analysis and both present the deletion in such gene. Therefore, it is quite probable that the previous phenotypes related before be related to a non-identified mutation present in the original strain in which those studies were performed.