Diphenyl diselenide, a simple diaryl diselenide, is active as a glutathione peroxidase mimic. This compound, injected subcutaneously, elicits significant and dose-related antinociception in chemical and thermal behavioural tests. The aim of the present study was to evaluate the antinociceptive effects of diphenyl diselenide, given oral, in chemical and thermical models of pain. Data were analyzed statistically by one-way ANOVA, followed by Duncan's Multiple Range Test when appropriate.Diphenyl diselenide (1-100 mg/Kg), given (30 min earlier) by oral route (p.o) in mice, inhibited acetic acid-, capsaicin-, glutamate-, bradykinin(BK)- and phorbol myristate acetate (PMA)-induced pain.  In addition, diphenyl diselenide reduced, glutamate-, BK- and PMA-induced paw oedema formation. Moreover, diphenyl diselenide (10 – 50 mg/Kg) caused a significantly increase in tail-flick response latency time in mice. Taking together, the results presented here revealed that diphenyl diselenide, orally administered in mice, produces antinociception in several models of pain.

CAPES, CNPq, UFSM