Pro and anti-inflammatory cytokines network in plasma samples of Fanconi anemia (FA) patients.
G.A. BARUQUE1,2; M.A. BITENCOURT3; R. PASQUINI3; M.T.L. CASTELO-BRANCO4; V. KOATZ1; V.M. RUMJANEK1
1Instituto de Bioquímica Médica/ CCS – UFRJ; 2Instituto de Biofísica Carlos Chagas Filho / CCS – UFRJ; 3Serviço de Transplante de Medula Óssea / Hospital de Clínicas – UFPR; 4Departamento de Histologia e Embriologia/ICB-CCS/UFRJ, Brazil
FA is an inherited complex failure disease, characterized by congenital malformations, progressive bone marrow failure and predisposition to cancer development. The risk for infections is increased in FA being the major cause of morbidity and mortality among FA patients during periods of neutropenia and even the first year after bone marrow transplantation. In this work we evaluated the cytokine microenvironment in plasma sample of 95 FA patients aiming to know the balance of pro and anti-inflammatory network. Plasma samples were analyzed using ELISA technique for TNF-α, INF-g, IL-10 and TGF-b1. The results showed increased levels of TNF-α and IL-10 in 14% and 25% of the samples analyzed respectively. These results may be of great value for the management issues and immunological aspects of FA.
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