Oral Therapy with Diphenyl Diselenide Protects against Toxic Effects Induced by Cadmium in Mice Testes
Ricardo Brandão; Francielli W. Santos; Renata de Oliveira; Gilson Zeni; João B.T. Rocha; Cristina W. Nogueira
Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios. Departamento de Química. Universidade Federal de Santa Maria Santa Maria – RS - Brasil
We evaluated the protector effect of diphenyl diselenide (PhSe)2 (200 and 400 m mol/kg), administered orally, on testicular damage induced by cadmium (2.5 and 5 mg/kg CdCl2, intraperitoneally). The effect of cadmium on d -aminolevulinic dehydratase (d -ALA-D) and catalase activities, lipid peroxidation, nonprotein thiols (NPSH) and ascorbic acid levels in mice testes were investigated. The parameters that indicate tissue damage such as plasma aspartate (AST) and alanine (ALT) aminotransferases, creatinine and lactato dehydrogenase (LDH) were also determined. The results demonstrated that oral therapy with (PhSe)2 was effective, at least in part, in protecting against the toxic effects of cadmium on d -ALA-D and LDH enzymes, on lipid peroxidation and on ascorbic acid content. Catalase activity was not modified after cadmium exposure and (PhSe)2 did not alter AST and ALT activities as well as creatinine levels. In conclusion, oral therapy with (PhSe)2 protected against acute toxicity induced by cadmium in testes of mice.
CAPES, CNPq (PIBIC)
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