XXXV Reunião Anual da SBBqResumoID:2344


Metabolically Obese but Normal-Weight Young Student Women.


Eleodoro, A.G.; Risso, J.B.; Xavier, A.R. and Lopes, P.F.



Centro Universitário de Rio Preto (UNIRP), CP161481631, 15025-040, São José do Rio Preto, SP, Brazil.



The concept of the metabolically obese normal-weight (MONW) individual was developed 20 years ago; however, has not been established so far. When it was first introduced, it suggested that MONW individuals were those whose BMI (body mass index) was considered normal but who, like overweight people, had any one of the following metabolic disorders: hyperinsulinemia, insulin-resistance, predisposition to type 2 diabetes, hypertriglyceridemia, and premature coronary heart disease. Since then, it has become increasingly clear that such MONW are very common the general population. Specific factors that appear to predispose MONW, as well as more obese individuals, to insulin resistance include central fat distribution and inactivity. The present study had the purpose to identify MONW among young women. There were 64 young normal-weight women who participated in the study. The inclusion criteria for participation were 1) age 18–35 years, 2) 18 < BMI < 26, 3) stable weight (±2 kg) over 6 months preceding the study, and 4) no regular participation in physical exercises during the 6 months before the study. Exclusion criteria for participation were 1) smoking, 2) acute illness, 3) use of any medication affecting energy expenditure, and 4) alcohol consumption >15 g/day. The family history of diabetes was obtained during the physical examination. Since the participants in our study were young women (<35 years old), parental age could have limited the detection of type 2 diabetes. Thus, we also considered the presence of type 2 diabetes among grandparents and the parents’ siblings as indicators of a positive family history. The use of oral contraceptives was also obtained in the medical history. The MONW women were determined using the diagnostic table proposed by Ruderman (1998). According Ruderman’s classification, 58% of analyzed population was considered MONW, besides the normal weight. The medical interview revealed that the students have bad feed habits, as well as family history of diabetes, hypertension and obesity. After analyzing the body composition we found high percentage of corporal fat deposition, besides the normal weight and BMI. The biochemical profile showed high serum levels of fast glucose, total cholesterol and triglycerides. In this way, some factors as bad feed habits, sedentary life style, elevated fat body percentage, familiar history of diabetes and hypertension, and dyslipidemia might be associated to the development of metabolic obesity.