This work describes some of the possible cognitive operations related to the use of an educational game type activity, which is part of the software e-metabolismo, developed to improve biochemical learning. This interactive activity, called DMDV  – Dynamic Metabolic Diagram, allows participants to drag-and-drop components of the sequence of chemical reactions, which describe the metabolic route under study. It also offers to the students quizzes and texts about the subject. The suggestion of cognitive processes possibly triggered by the software, which must improve effective learning, was based on Jean Piaget’s genetic epistemological ideas to explain the cognitive activity. One of these processes is the mere act of playing the game, which Piaget relates to humans needs of learning rules of socialization. It also can be seen as a first step in cognition process, the so called adaptation function that include assimilation and accommodation, interactive processes between intelligent activities and elements from the reality, to became part of the individual´s mental structures. Another example: drag and drop substracts and enzymes pieces in a virtual board, each one corresponding to an specific place in a metabolic route. This operation can be related to motivation, an affective element proposed by Piaget to stimulate curiosity and improve construction of knowledge structures. Besides this issue, the act of choosing pieces is assumed to inform the student previous knowledge (previous cognitive structures), which, according to Piaget, must be misbalanced (equilibration of new structures is supposed to be part of the dynamic process of organization of new knowledge). DMDV was tested with a group of 24 students (2003) and another group of 36 students in 2004, of a Biochemistry Course regularly registered at FFFMCPA´s medicine faculty. The evaluation of the student’s apprenticeship was made by a conventional test and three Conceptual Maps constructed by each student, (a) before playing the game, (b) immediately after, and (c) three months after the use of the game.